POLR3B

GENERAL INFORMATION

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Gene name

POLR3B

Gene description

Polymerase (RNA) III (DNA directed) polypeptide B

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Supportive based on 1 antibody.
HPA036466
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

POLR3B (HGNC Symbol)

Synonyms

FLJ10388, RPC2

Description

Polymerase (RNA) III (DNA directed) polypeptide B (HGNC Symbol)

Entrez gene summary

This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

12

Cytoband

q23.3

Chromosome location (bp)

106357658 - 106510198

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000013503 (version 78.38)

Entrez gene

55703

UniProt

Q9NW08 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NW08

Antibodypedia

POLR3B antibodies


PROTEIN BROWSER

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ENST00000228347
 
ENST00000539066
 
ENST00000549569
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POLR3B-001 ENSP00000228347
ENST00000228347
Q9NW08
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Show » Show » 1133 127.8 No 0
POLR3B-003 ENSP00000445721
ENST00000539066
Q9NW08
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Show » Show » 1075 121.1 No 0
POLR3B-004 ENSP00000448398
ENST00000549569
F8VRU2
Show all »
Show » Show » 170 19.6 No 0