BAD

GENERAL INFORMATION

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Gene name

BAD

Gene description

BCL2-associated agonist of cell death

Protein class

Cancer-related genes
Mitochondrial proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA028185 , HPA062105 , CAB004205
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

BAD (HGNC Symbol)

Synonyms

BBC2, BCL2L8

Description

BCL2-associated agonist of cell death (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

64269830 - 64284704

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000002330 (version 78.38)

Entrez gene

572

UniProt

Q92934 (UniProt - Evidence at protein level)

neXtProt

NX_Q92934

Antibodypedia

BAD antibodies


PROTEIN BROWSER

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ENST00000309032
 
ENST00000394531
 
ENST00000394532
 
ENST00000492141
 
ENST00000493798
 
ENST00000544785
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAD-001 ENSP00000309103
ENST00000309032
Q92934
Show all »
Show » Show » 168 18.4 No 0
BAD-002 ENSP00000378040
ENST00000394532
Q92934
Show all »
Show » Show » 168 18.4 No 0
BAD-003 ENSP00000378039
ENST00000394531
A8MXU7
Show all »
Show » 163 16.9 No 0
BAD-004 ENSP00000438975
ENST00000493798
F5H1R6
Show all »
Show » 64 7.3 No 0
BAD-005 ENSP00000439202
ENST00000492141
F5H3B1
Show all »
Show » 51 5.8 No 0
BAD-008 ENSP00000440575
ENST00000544785
F5GYS3
Show all »
Show » 157 16.6 No 0